MTOR and neoplasm: In addition, GSEA based on HALLMARK pathways suggested that tumor hallmarks, such as E2F targets, MTORC1 signaling, MYC targets V1, NOTCH signaling, the P53 pathway, Pl3K/AKT/mTOR signaling, TGF BETA signaling, and WNT/BETA CATENIN signaling, were significantly enriched in the high-risk group (Figure 8E and Supplementary Table S10).