Furthermore, the GSEA results depicted high enrichment of pathways and hallmarks related to tumor progressions in the high-risk group, such as cell cycle, bladder cancer, DNA replication, ubiquitin-mediated proteolysis, MTOR signaling pathway, TGF BETA signaling, E2F targets, MTORC1 signaling, P53 pathway, MYC targets V1, NOTCH signaling, Pl3K/AKT/mTOR signaling and WNT/BETA CATENIN signaling. This evidence concerns the gene AKT1 and urinary bladder cancer.