In a recent study by Hsu et al. (2018), deleterious mutations in PTPRT/PTPRD were related to BV response states of metastasis CRC patients, with the enrichment of deleterious mutations occurring in non-responders, and patients with deleterious alterations showed a shorter PFS (Hsu et al., 2018). The gene discussed is PTPRD; the disease is colorectal carcinoma.