Gene modification plays an important role in tumorigenesis, and anomalies of many related signal transduction pathways, such as MAPK pathway, PI3K/AKT/mTOR pathway, WNT/β-catenin pathway, and JAK/STAT pathway, are also related to the progression of HCC (Mir et al., 2021). Here, PIK3CA is linked to hepatocellular carcinoma.