In published studies, AGRN (Zou et al., 2019), ITGAV (Zhang et al., 2019; Weiler et al., 2020), FLNC (Qi et al., 2016; Yang et al., 2017), ILK (Chan et al., 2011), and RSU1 (Gkretsi and Bogdanos, 2015) were overexpressed in HCC tumor tissues, thereby promoting tumor development, metastasis, and even leading to poor prognosis, which is consistent with our findings. The gene discussed is RSU1; the disease is hepatocellular carcinoma.