A total of 10 key ECM-related genes were obtained from ECM-related pathways to construct a novel prognostic prediction signature, including TRAPPC4, RSU1, ILK, LAMA1, LAMB1, FLNC, ITGAV, AGRN, ARHGEF6, and LIMS2. Previous studies have demonstrated that these 10 ECM-related genes are associated with the prognosis of various types of cancer, especially HCC. Here, LIMS2 is linked to hepatocellular carcinoma.