Multiple pieces of evidence indicated that PRGs are differentially expressed in psoriasis, such as GSDMD, caspase-1/2, IL-1 family genes (Lachner et al., 2017), NLRP1, NLRP3 (Deng et al., 2019), and AIM2 (Ciążyńska et al., 2021). The gene discussed is CASP1; the disease is psoriasis.