Through the experimental verification of 10 PRGs obtained by machine learning, it was found that the mRNA expression of IL-1β, AIM2, CASP4, CASP1, CASP8, GZMB, especially IL-1β, CASP1, CASP8, and GZMB, was ameliorated to alleviate the skin lesions IMQ-induced psoriasis-like mice, which provided potential therapeutic targets. Here, CASP4 is linked to psoriasis.