Upregulation-trends of Ptgs2 in ferroptosis was further demonstrated in the study by Zhou et al. In this study, they found that the expression of PTGS2, ACSL4, caspase-1, and NLRP3 were upregulated at the late stages of atherosclerosis, and these proteins could be used as biomarkers of atherosclerosis severity (Zhou and Zhou, 2021). The gene discussed is CASP1; the disease is atherosclerosis.