ACHE and Cognitive impairment: Matrine structure can restore Th17/Treg cytokine balance and alleviate cognitive impairment in Alzheimer’s disease rats in a dose-dependent manner (Zhang et al., 2015); MT can improve scopolamine-induced amnesia by inhibiting acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities (Sun et al., 2019a).