Although genotype–phenotype correlation has not been demonstrated for a specific clinical spectrum for the individual mutations in ALMS1 in all reported articles on cardiomyopathies, we think that the c.7911dupC (p. Asn2638Glnfs*24) mutation may be one of the significant determinants of the severe cardiomyopathy. The gene discussed is ALMS1; the disease is cardiomyopathy.