Since TGF-β plays an important role in promoting cell proliferation and malignancy of MM cells through CTGF protein expression (11), we have checked the alteration of Smad2/3 phosphorylation and transactivation of TGF-βgenes in BAMBI knocked down Y-MESO-14 and Y-MESO-27 cells. This evidence concerns the gene BAMBI and Miyoshi myopathy.