ANO1 and gastrointestinal stromal tumor: ICLC possess morphological and molecular congruences with the interstitial cells of Cajal in the gastro-intestinal tract. The cells express Platelet-derived growth factor receptor α (PDGFRα), which, besides DOG1 (Discovered on GIST-1 = Anoctamin 1/ANO1), is a marker for gastro-intestinal stroma tumor (GIST) [39].