C12orf75 and argyrophilic grain disease: Simple pairwise testing of weight-adjusted metabolic rate measures revealed a significant decline of such with increasing AGD severity (SMR: AGD0 vs. AGD 2: p = 0.01; AGD0 vs. AGD3: p = 0.004; MMR: AGD0 vs. AGD 2: p = 0.02; AGD0 vs. AGD3: p = 0.005; AS: AGD0 vs. AGD3: p = 0.03; Fig. 3).