In two HCC patient cohorts (cohort I, n = 260; cohort II, n = 280), ETV1 expression was correlated with PTK2 and c-MET expression (Fig. 7A, B), and elevated expression of PTK2 or c-MET was associated with poor tumor differentiation, microvascular invasion, loss of encapsulation, and advanced TNM stage (Table S5 and S6). This evidence concerns the gene MET and neoplasm.