To address the effects of PTK2 and c-MET on ETV1-mediated HCC metastasis, we downregulated PTK2 and c-MET expression in PLC/PRF/5-ETV1 cell line and upregulated PTK2 and c-MET expression in MHCC97H-shETV1 cell line with lentiviral infection (Fig. S4A, B, Fig. 4A and Table S4). The gene discussed is PTK2; the disease is hepatocellular carcinoma.