Since ERK1/2 inhibitor inhibited ETV1 upregualtion induced by HGF (Fig. 5D), to better ascertain the role of ERK1/2-ETV1 in HGF-mediated HCC cell invasion and migration, we investigated the effect of ERK1/2 inhibitor SCH772984 on migration and invasion of PLC/PRF/5 cells mediated by recombinant HGF. Here, MAPK3 is linked to hepatocellular carcinoma.