The core targets of yellow tea for the treatment of hyperuricaemia were detected by MCODE and consisted of NLRP3 inflammasome (NLRP3), peroxisome proliferator-activated receptor-α (PPARA), IL-1β (IL1B), interleukin-6 (IL6), tumour necrosis factor (TNF), peroxisome proliferative activated receptor gamma (PPARG), C–C motif chemokine ligand 2 (CCL2), vascular endothelial growth factor A (VEGFA), and signal transducer and activator of transcription (STAT3) (Additional file 1: Table S1). Here, NLRP3 is linked to hyperuricemia.