PM20D1 and Alzheimer disease: The comparison with our previous sex-combined analysis of AIBL and ADNI EWAS [22] showed a small number of AD-associated CpGs and DMRs (4/23 CpGs and 1/41 DMRs in females, 1/4 CpGs, and 3/24 DMRs in males), including the DMR located in the promoter of the PM20D1 gene we described above, were identified by both analyses (Supplementary Tables 2, 3, and 5), suggesting that DNA methylation differences at these loci were predominately driven by effects in only one sex.