In prefrontal cortex brain samples, we found several of these target genes, including LGALS3BP, RNASET2, TAGLN3, VAMP5, ALOX12 in females, and PGPEP1, KCTD11, STK32C, FANCA in males, are differentially expressed in AD (Supplementary Table 8c, 9c). This evidence concerns the gene VAMP5 and Alzheimer disease.