At 5% FDR, among the significant sex-specific AD-associated CpGs and CpGs located in AD-associated DMRs, in females, DNAm at 23 CpGs (mapped to 5 DMRs) in gene promoter regions were significantly associated with the expression of their target genes, including LGALS3BP, VAMP5, ALOX12, TAGLN3, and GABRG1 (Supplementary Table 8). Here, VAMP5 is linked to Alzheimer disease.