GWAS have fine-mapped an intergenic variant near CTRB2 (rs72802342, CPP=0.66) that is associated with T2D [1], T1D [5], and pancreatic ductal adenocarcinoma (PDAC) [57] and co-localizes with an accessible chromatin region in human acinar cells and islets [5, 58]. This evidence concerns the gene CTRB2 and type 2 diabetes mellitus.