Islet sGenes were enriched in islet-specific co-expression networks (Fig. 1j) and included numerous genes with well-established roles in islet biology and diabetes (Additional file 4: Table S3), including major drug targets (GLP1R, DPP4, ABCC8), regulators of hormone secretion (SLC7A2, CASR, GIPR), transcription (NKX6-1, PAX6, MLXIPL/ChREBP), signaling (DYRK1A, WNT4), or circadian rhythms (PER3, CRY1, NR3C1, NR0B2). The gene discussed is DYRK1A; the disease is diabetes mellitus.