After knocking down of Glut1 gene in 4T1 cells, cellular uptake of Rg3-Lp was reduced to a level comparable to that of C-Lp, suggesting that Rg3-Lp can be preferentially uptake by tumor cells via the interaction between Rg3’s glycosyl units extending outside and Glut1 overexpressed on tumor cells, thereby realizing more tumor site accumulation than C-Lp. This evidence concerns the gene SLC2A1 and neoplasm.