Unlike the in vitro results showing that Rg3 and Rg3-Lp have comparable inhibition efficacy of tumor-CAFs interaction, the level of TGF-β concentration and signaling in tumors of Rg3-Lp group was much lower than that in free Rg3 group (Fig. 5E–H) in vivo owing to the enhanced targeting delivery capacity when Rg3 was formulated into liposomes. This evidence concerns the gene TGFB1 and neoplasm.