Patients with type 2 DM and ischemic stroke had higher serum CCL7 levels than patients with ischemic stroke alone [58]. Although the recruitment of immune cells to adipose tissue is altered in obesity, which causes insulin resistance in type 2 DM, the dominant factor for recruiting macrophages in adipose tissue during obesity should be further defined [59]. Here, CCL7 is linked to obesity due to melanocortin 4 receptor deficiency.