TEK and influenza: Restoring the disturbed balance between phosphorylated and non-phosphorylated Tie2, the synthetic polyethylene glycol (PEG) clustered Tie2 agonist Vasculotide (VT)29 has been shown to reduce endothelial permeability in models of abdominal sepsis30, hemorrhagic shock31, cardiopulmonary bypass32, influenza33, and pneumococcal pneumonia34, even improving survival in influenza and abdominal sepsis30,33.