Moreover, we analysed the metabolic profiling of renal cell carcinoma (RCC) patients, among which 394 received nivolumab, a PD1 checkpoint blockade, and 349 received everolimus, an mTOR inhibitor (Phase III trial: CheckMate 025, NCT01668784)15,26. The gene discussed is MTOR; the disease is hereditary clear cell renal cell carcinoma.