CD8A and neoplasm: In addition, the UBA6 protein expression level on tumour cells was negatively correlated with CD8+ T cells infiltration in the TME (R = 0.64, P < 0.01, Supplementary Fig. 8d), indicating that tumoural UBA6-low expression is associated with a strong antitumour immune response, consistent with the finding in the mouse tumour models (Fig. 2f).