MTOR and cancer: Specifically, the higher level of inosine was associated with the longer OS of cancer patients only in the setting of nivolumab treatment (high: mOS = 33 months; low: mOS = 22 months), but not in cancer patients treated with everolimus (an mTOR inhibitor) (Fig. 1b), indicating that high level of inosine had a durable benefit for ICB-treated patients.