Assumed reasons for CARS are direct apoptosis of dendritic cells, B cells and CD4+ and CD8+ T cells, a higher proportion of Tregs, that have shown to be less vulnerable to sepsis-induced apoptosis and to enhance anti-inflammatory regulation, and a deviation from Th1-dominated initial pro-inflammatory response to a Th2-dominated anti-inflammatory immune response13,19,20. Here, CD8A is linked to Sepsis.