We also applied the Labrecque transcription-based classifier that was developed on rapid autopsy CRPC samples and identified five subsets of prostate cancer: AR-driven prostate cancer (ARPC), amphicrine prostate cancer with neuroendocrine gene expression concomitant with AR signaling, AR-activity low prostate cancer, DNPC, and NEPC23. This evidence concerns the gene AR and Familial prostate cancer.