Reduction of VCAM-1 and intercellular adhesion molecule 1 (ICAM-1) by CBD treatment has also been reported in an animal model of diabetes-induced cardiomyopathy, high glucose-induced endothelial cell barrier disruption, and in TNF-α exposed sinusoidal epithelial cell assays [65–67]. The gene discussed is TNF; the disease is cardiomyopathy.