In a mouse model of middle cerebral artery occlusion (MCAO), CBD treatment reduced neurological impairment following stroke by inhibiting myeloperoxidase (MPO) containing cell expression of HMBG1, inhibiting macrophage/monocyte expression of HMBG1, reducing HMBG1 plasma levels, and preventing glial activation [52]. The gene discussed is MPO; the disease is stroke disorder.