Animal models of CDKL5 disorder, Cdkl5 knockout (KO) mice [12–14], recapitulate different features of CDD, exhibiting severe impairment in learning and memory, visual and respiratory deficits, and motor stereotypies [12, 13, 15–17] and, therefore, they are a good model with which to study the positive effects of therapeutic strategies. This evidence concerns the gene CDKL5 and craniodiaphyseal dysplasia.