CDKL5 and viral infectious disease: Importantly, no changes in terms of body weight, sleep pattern, microglial cell number, or cell survival were observed in vector-treated Cdkl5 − /Y mice compared to age-matched vehicle-treated mice (Supplementary Fig. 3b–d), indicating that viral infection and secreted CDKL5 protein did not affect animal well-being and/or cause an inflammatory response.