CDKL5 and craniodiaphyseal dysplasia: Since impaired breathing pattern, particularly during sleep, and visual responses represent promising biomarkers for preclinical and clinical studies on CDD [22, 28, 29, 33], we evaluated the effect of the treatments with AAVPHP.B_Igk-TATk-CDKL5 and AAVPHP.B_CDKL5 vector on these two patterns in Cdkl5 − /Y mice.