CDKL5 and infection: With the same infection efficacy as that of the AAVPHP.B_CDKL5 vector, a gene therapy with AAVPHP.B_Igk-TATk-CDKL5 was sufficient to improve various behavioral defects in the Cdkl5 − /Y mouse, such as innate behaviors and motor performance, and to ameliorate visual function.