HNF1B and neurodevelopmental disorder: 10 11 Protein-truncating variants (PTVs) in HNF1B cause a similar phenotype6 12 13; however, HNF1B PTVs are not associated with neurodevelopmental disorders.14 It is unknown whether HNF1B triplosensitivity contributes to the phenotypes observed in individuals with 17q12 microduplications or whether other genes in the region also play a role in the deletion or microduplication phenotypes.