We also found associations between rare PTV/missense variants in C17orf78 with elevated cystatin C (ß=0.51, 95% CI 0.23 to 0.80, p=3×10−4) and SYNRG with increased risk of bipolar disorder (OR=27.45, 95% CI 3.03 to 248.61, p=8×10−4). This evidence concerns the gene SYNRG and bipolar disorder.