Since then, additional genetic variation at the CFH locus has been reported to confer either increased risk (rs570618, rs121913059, rs187328863, rs35292876, rs191281603) or a decreased risk (rs10922109, rs148553336, rs61818925) for AMD (Supplementary Fig. 2) (Fritsche et al., 2016). The gene discussed is CFH; the disease is age-related macular degeneration.