FHR-4 levels were strongly associated with variants at the CFH locus, where AMD risk-conferring variants (rs570618, rs187328863) were associated with increased FHR-4 levels, while protective variants (rs10922109, rs61818925) were associated with decreased FHR-4 levels (Cipriani et al., 2020). Here, CFH is linked to age-related macular degeneration.