Coding variants in these genes include the variants p. Gly119Arg (rs141853578) in CFI, p.Arg102Gly (rs2230199) and p. Lys155Gln (rs147859257) in C3, and Pro167Ser (rs34882957) in C9, which are associated with an increased risk of AMD. This evidence concerns the gene CFI and age-related macular degeneration.