C3 and age-related macular degeneration: Recently, the EYERISK consortium developed a genetic test for AMD that allows genotyping of all 52 AMD-associated genetic variants, rare variants in AMD-associated genes including several complement genes (CFH, CFI, C3, C9), and genes that are involved in the pathogenesis of inherited macular dystrophies because the phenotype of some of these dystrophies can mimic AMD, such as ABCA4 (a cause of Stargardt disease) and PRPH2 (a cause of central areolar choroidal dystrophy) (de Breuk et al., 2021a).