Coding variants in these genes include the variants p. Gly119Arg (rs141853578) in CFI, p.Arg102Gly (rs2230199) and p. Lys155Gln (rs147859257) in C3, and Pro167Ser (rs34882957) in C9, which are associated with an increased risk of AMD. The gene discussed is C3; the disease is age-related macular degeneration.