SNCA and multiple system atrophy: In the α-synuclein filament structures of MSA, E46 forms a salt bridge with K80, whereas E35 forms a salt bridge with K80 in PD, PDD and DLB (Figure 3) This may explain why DLB seeds, unlike those from MSA, induced the seeded assembly of E46K α-synuclein in HEK cells (31,51).