OPN1MW and Dravet syndrome: Children with Dravet syndrome and Lennox–Gastaut syndrome have been reported to respond favorably to CBD at doses of 10–20 mg/kg/day,1,2,7 and the current clinical and experimental literature suggests that therapeutic plasma concentrations of CBD may range between 100 nM and 10 μM, with the high nM to very low μM range being most clinically relevant.1,5,6,8 In rodents, CBD has antiseizure effects over a broad dose range (5−400 mg/kg)6; however, CBD plasma concentrations in earlier studies have not been consistently reported.