When the protein expression changes associated with epithelial-mesenchymal transition were analyzed (Fig 4a), the TGF-β level decreased 6.25±0.35 (p˂0.001) times in the Exo-PAC group, SMAD level was 1.86±0.2 (p˂0.01) times, Slug level decreased 3.65±0.8 times (p˂0.001), Notch level changed 1.12±0.15 times. The gene discussed is SNAI2; the disease is gonorrhea.