The genes included in each of the six DDPP predictors are presented in detail in the Data Supplement and illustrate a significant enrichment in cancer-related biological pathways (control of transcription factors, control of cell cycle and proliferations, ubiquitin degradation of proteasome, and mitogen-activated protein kinase) indicating that ACC, SCC, and LCC are distinct diseases at the biological level. The gene discussed is WNK2; the disease is leukoencephalopathy with calcifications and cysts.