Pathway enrichment analysis using the MsigDB Hallmark 2020 database showed that the key pathway included in the DDPP predictor of the AC patients treated with surgery only was the G2-M checkpoint control (P = .0042 and adjusted P value for multiple comparisons = .012) while the key pathway for genes in the SCC predictor was IL6/JAK/STAT3 signaling (P = .0018, adjusted P = .015), and the key pathway in the LCC predictor was KRAS signaling pathway (adjusted P = .04). The gene discussed is IL6; the disease is leukoencephalopathy with calcifications and cysts.