Regarding CD8+ cells, the acute infection by T. cruzi increased Vβ2, 4, 6, 7, 8, and 9 thymocytes, Vβ8 T cells in the lymph node, and Vβ5, 6, and 14 spleen cells, while Vβ8.1 and 8.2 were decreased in the spleen [37,39,40]. This evidence concerns the gene CD8A and infection.