With the expansion of the catalogue of anti-Vβ and anti-Vα antibodies, as well as advances in TCR next-generation sequencing techniques, which are more sensitive and accurate in detecting and quantifying rare clonotypes and to decipher the complexity of TCR repertoire, there is a tendency to use more analysis of the TCR repertoire in the context of Chagas disease [70,71]. Here, COX5A is linked to Chagas disease.