EIF2AK4 and posterior cortical atrophy: For example, a mitochondrial Rho GTPase 2 (MIRO2) overexpressed in PCa was recently shown to bind to GCN1, a critical activator of GCN2 (Furnish et al., 2022), and certain mitochondrial defects were reported to contribute to activation of GCN2 and the ISR (Mick et al., 2020).