EIF2AK4 and posterior cortical atrophy: This correlation was more striking among tissues from higher grade tumors (r = 0.47, p = 0.002, Gleason scores 4 and 5) (Figure 7G), which was further supported by staining of p-GCN2 and 4F2 (SLC3A2) of core needle biopsy specimens from patients with high-grade PCa (Figure 7—figure supplement 3B).