For example, a mitochondrial Rho GTPase 2 (MIRO2) overexpressed in PCa was recently shown to bind to GCN1, a critical activator of GCN2 (Furnish et al., 2022), and certain mitochondrial defects were reported to contribute to activation of GCN2 and the ISR (Mick et al., 2020). This evidence concerns the gene RHOT2 and posterior cortical atrophy.