In response to inflammatory conditions or acute injury to the nervous system, such as viral infection, autoimmune disease, and stroke, and in the setting of complex neurological disorders, including Alzheimer’s disease (AD) and experimental autoimmune encephalitis (EAE), p75NTR is upregulated and may adversely affect neuronal function (15, 21). Here, NGFR is linked to early-onset autosomal dominant Alzheimer disease.