In response to inflammatory insults or acute injury, such as traumatic brain or spinal cord injury (55, 56), viral infection (57), and stroke (44), and in the setting of complex neurological disorders, including AD (58) and EAE, (the mouse model of MS) (15, 21), p75NTR is upregulated and can adversely affect neuronal function. Here, NGFR is linked to nervous system disorder.