IHC staining of SOX10, a melanoma transcription factor expressed through early to late stages in this model (23, 24), confirmed that the pigmented cells corresponded to SOX10+ melanoma cells whose number was reduced in ears of Braf/Pten/Tslp–/– mice (Figure 1F; see also Supplemental Figure 3 for cell counting). The gene discussed is PTEN; the disease is melanoma.