Nevertheless, the DC-mediated mechanism for the TSLP/GATA3+(ST2+) Treg axis reported here differs from that reported by Obata-Ninomiya et al. (50), who show that TSLP signals directly via TSLPR predominantly expressed by ST2+ Tregs in mouse and human colon cancer. The gene discussed is CRLF2; the disease is colonic neoplasm.