Moreover, Sishenwan increases the mRNA expression of IL-4 and IL-10 and thus inhibits the production of proinflammatory factors (TNF-α and IL-1).[64] Therefore, Sishenwan can effectively inhibit the mRNA expression of apoptosis-related molecules in the p38 MAPK signaling pathway and thereby decreases the apoptosis of colonic mucosal epithelial cells in mice with intestinal inflammation. This evidence concerns the gene IL10 and inflammation.