Relevant studies have shown that Sishen pills inhibit the expression of p53, caspase-3, c-Fos, c-Jun, TNF-α, and Bax mRNA,[62] similar to the results reported by Liu et al,[63] improve colitis in mice and increase the level of Bcl-2 mRNA and the Bcl-2/Bax ratio. The gene discussed is CASP3; the disease is colitis.