Moreover, Sishenwan increases the mRNA expression of IL-4 and IL-10 and thus inhibits the production of proinflammatory factors (TNF-α and IL-1).[64] Therefore, Sishenwan can effectively inhibit the mRNA expression of apoptosis-related molecules in the p38 MAPK signaling pathway and thereby decreases the apoptosis of colonic mucosal epithelial cells in mice with intestinal inflammation. The gene discussed is TNF; the disease is inflammatory response.