According to the manifestations of fever, splenomegaly, anemia and thrombocytopenia, hyperferritinaemia, hyperglyceridemia and elevated IL-2R, the diagnosis of hemophagocytic syndrome was made on the basis of the HLH-2004 diagnosis criteria.[1] The patient was then referred to the department of hematology. Here, IL2RA is linked to Splenomegaly.