An experimental model suggested that endothelial cells in LAL-D mice facilitated in vivo tumor angiogenesis, growth, and metastasis, largely by stimulating tumor cell proliferation, adhesion, and transendothelial migration via increased expression of interleukin-6 and monocyte chemoattractant protein 1.[17] The role of PPAR-alpha and mTOR pathways for tumor stimulation in LAL-D hepatocytes has also been studied, but no specific mutation in the gene LIPA has so far been strongly associated with malignancies.[18]. This evidence concerns the gene IL6 and neoplasm.