By inhibiting macrophage apoptosis, consuming CD4 + T lymphocytes affecting the functional structure of granulomas and other complex immune responses, HIV makes it difficult for the body to effectively limit the growth and dissemination of MTB, and increases significantly the risk of active pulmonary TB and its extrapulmonary transmission.[2] The impact of HIV infection on the spread of TB is controversial. This evidence concerns the gene CD4 and tuberculosis.