In our study, although CRP/Alb was not an independent factor affecting the OS rate of osteosarcoma patients, both univariate and survival curve analyses suggested that high CRP/Alb is indicative of a poor prognosis for osteosarcoma; therefore, there is still reason to believe that CRP/Alb is a potentially useful indicator for predicting the survival rate in osteosarcoma. This evidence concerns the gene ALB and osteosarcoma.