The results showed that tumor volume (hazard ratio [HR] = 1.061; 95% confidence interval (CI), 1.001–1.125; P = .046) and preoperative P-CRP (HR, 1.037; 95% CI, 1.024–1.050; P < .01) were independent prognostic factors affecting the postoperative OS of osteosarcoma patients (Table 3). The gene discussed is CRP; the disease is osteosarcoma.