A study by Ide S et al[10] included 135 patients with locally advanced rectal cancer; the optimal cut-off value was 4.11, the survival curves showed that the OS of the high P-CRP group was lower than that of the low P-CRP group, and P-CRP was determined to be an independent factor affecting the prognosis of locally advanced rectal cancer patients. The gene discussed is CRP; the disease is rectal cancer.