Artemisinin and its derivatives inhibit NF-κB signaling activity by blocking several upstream NF-κB signaling pathways, resulting in the downstream inhibition of a series of activities, including the release of pro-inflammatory factors.[7] As a derivative of artemisinin, artemether can improve the inflammatory state in rheumatoid arthritis, diabetes, neuritis, and other diseases, mainly by inhibiting the expression of IL-2, IL-6, IFNγ, and other itchy inflammatory mediators.[9,10,20–22] Our study confirmed the anti-inflammatory effects of artemether. This evidence concerns the gene NFKB1 and rheumatoid arthritis.