The low level of % stromal TILs (hazard ratio, HR = .980, 95% CI .963–.998, P = .029) and B2M (HR = 1.000, 95% CI .999–1.000, P = .033), and high expression levels of CD44 (HR = 1.010, 95% CI 1.001–1.020, P = .039), PTPN11 (HR = 1.068, 95% CI 1.012–1.128, P = .017), and TRIM74 (HR = 26.495, 95% CI 1.229–571.371, P = .036) were associated with a poor DFS in NPC (Table 2). Here, PTPN11 is linked to nasopharyngeal carcinoma.