Statistical analysis showed that genes LUC7L3, CXCL10, and XRCC5 were upregulated in advanced NPC tumors (III or IV) compared with early-stage tumors (I/II), while the B2M gene was downregulated in advanced NPC tumors (P < .05; Fig. 5A). The gene discussed is B2M; the disease is nasopharyngeal carcinoma.