In contrast to anti-Ro antibodies, which may be present in a variety of autoimmune diseases, anti-La antibodies are specific for the diagnosis of SLE and Sjögren syndrome.[20] In addition, as with anti-Ro antibodies, anti-La antibodies may be detected in the mothers of children who are born with neonatal lupus syndrome. This evidence concerns the gene CALR and systemic lupus erythematosus.