Emerging evidence implicates stromal inflammation in the PDAC tumor microenvironment (TME)—predominantly through inflammatory polarization of cancer-associated fibroblasts (iCAF) and CAF-derived secretion of IL-6 (Öhlund et al., 2017)—as a major driver of chemoresistance in PDAC (Hosein et al., 2020). This evidence concerns the gene IL6 and neoplasm.