ITGAM and neoplasm: In tumor-bearing animals, NLR attenuation significantly reduced—but did not abolish—circulating Ly6G+Ly6CdimF4/80- neutrophilic cells, although a compensatory increase in Ly6ChiLy6G-F4/80- monocytic cells was observed via flow cytometry from splenocyte-derived CD11b+ cells (Figure 3A).