Systemic NLR attenuation with anti-Ly6G treatment—with or without chemotherapy—resulted in significant diminution of IL-1β secretion in tumor lysates compared with vehicle or chemotherapy treatment in vivo (ANOVA p<0.001; Figure 5B), likely due to its incident reduction in systemic and tumor-infiltrating Ly6G+ cells (see Figure 3). Here, IL1B is linked to neoplasm.