IL1B and neoplasm: To explore a mechanistic link between tumor-infiltrating neutrophils and iCAF-mediated IL-6/STAT-3 signaling in the PDAC TME, we characterized the secretome of tumor-infiltrating Ly6G+F4/80- neutrophils isolated from orthotopic KPC tumors, revealing IL-1β as the most robustly secreted cytokine (Figure 5A).