Ex vivo co-cultures of KPC CAFs with tumor-infiltrating Ly6G+F4/80- neutrophils derived from orthotopic tumor-bearing KPC mice induced a nearly 20-fold increase in CAF-intrinsic Il6 transcription (p<0.0001), which was significantly abrogated by either neutralization of IL-1β (p<0.0001) or by pre-incubation of CAFs with IL-1R1 inhibitor Anakinra (Nagathihalli et al., 2016; p<0.0001; Figure 5C). This evidence concerns the gene IL1B and neoplasm.