Taken together, SCF can modulate cytokines secretion by mast cell and the modulation mainly shown by an increase in various pro-inflammatory cytokines and a decrease a small number of anti-inflammatory cytokines; however, 2G4 antibody exhibits therapeutic efficacy against mast cell diseases by inhibiting SCF-mediated cytokine modulation, which accelerates the progression and symptoms. The gene discussed is KITLG; the disease is maculopapular cutaneous mastocytosis.