We found that P2Y11 promoted the release (shedding) of soluble TNF receptors through TNF-α converting enzyme (TACE), also known as ADAM17 (a disintegrin and metalloprotease 17), both in astrocytoma cells (sTNFR1) and in human M2 macrophages (sTNFR2). This evidence concerns the gene P2RY11 and astrocytoma (excluding glioblastoma).