TP53 and nasopharyngeal carcinoma: For the function of lncRNA ROR in NPC, Li found that lncRNA ROR was significantly upregulated in NPC tissues and was highly associated with the proliferation, metastasis and apoptosis of NPC, in addition, the enrichment of lncRNA ROR played a critical role in chemoresistance through suppressing p53 signal pathway (Li et al. 2016); Hong found that the upregulation of lncRNA ROR could be inhibited by polyphyllin I, resulting in suppressing tumor growth and promoting apoptosis in vitro and in vivo (Hong et al. 2019).