CFH and age-related macular degeneration: There are genetic loci that confer significant risk in the development of AMD including complement factor H (CFH), which are now under investigation as therapeutic targets (Table 2) (Wong et al. 2014a, b; Green and Key 1977; Johnson et al. 2001; Gehrs et al. 2006; Hollyfield et al. 2008; Ferrara 2010; Ambati and Fowler 2012; Ding et al. 2009).