Included: Cardiovascular history, hypertension, diabetes mellitus, current smoker, alcohol use, current medication (beta-blockers, other antihypertensive agent, antithrombotic agent, lipid-lowering agent, insulin or antidiabetic oral medication, psychotropic agents, hypothyroidism agent). Excluded: current OSA treatment, cardiovascular or respiratory comorbidities, and/or excessive daytime sleepiness justifying immediate initiation of CPAP, respiratory or heart disease contraindicating exercise discovery during stress testing, Parkinson’s disease.Frequent ectopic beats (>0.7%). The gene discussed is INS; the disease is Parkinson disease.