Immunohistochemistry (IHC) assay showed that P-gp-positive area in tumor tissues of mice subjected to GQ, ADR combined with GQ or/and miR-451 was obviously less than that in control group, and P-gp-positive area was the least in the group treated with ADR combined with GQ and miR-451 (Figure 7A, 7B). Here, PGP is linked to neoplasm.