Primary human myeloma cells modulated miR-27b-3p and miR-214-3p expression in fibroblasts through the release of EVs, which triggered proliferation and apoptosis resistance in myeloma fibroblasts via the FBXW7 and PTEN/AKT/GSK3 pathways, respectively (71). The gene discussed is AKT1; the disease is plasma cell myeloma.