In knockin syngeneic AML/acute lymphoblastic leukemia (ALL) mouse models, tumor-derived EVs increased the expression of adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) enzymes in adipocytes, resulting in increased lipolysis, which supported leukemia cell expansion (53). The gene discussed is PNPLA2; the disease is acute lymphoblastic leukemia.