HMOX1 and amyotrophic lateral sclerosis: With the oral supplementation of Acetyl-11-keto-beta-boswellic acid, a multi-component pentacyclic triterpenoid mixture, and an Nrf2/HO-1 activator, the myelin basic protein (MBP) increased in the brain homogenate, suggesting a potential role of Nrf2/HO-1 mediated signaling pathway of MBP restoration in ALS[52].