Moreover, their expression is further correlated with tumor grade and vital status underscoring their possible contribution to clinical outcome and prognosis through elevated levels of TXNDC5 in tumor tissues of both LGG and GBM patients, its gradual increase with the tumor grade, its strong elevation in deceased patients, and the presence of literature pinpointing its oncogenic nature10 encouraged us to investigate its role in glioma progression further. The gene discussed is TXNDC5; the disease is central nervous system cancer.